Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users

Francis Ribeiro de Souza; Marcelo Rodrigues dos Santos; Carlos Eduardo Rochitte; Rafael Parenquine dos Santos; Camila Paixão Jordão; Ivanhoe Stuart Leite; Guilherme Wesley Peixoto da Fonseca; Rafael Almeida Fonseca; Tiago Franco de Oliveira; Maurício Yonamine; Rosa Maria Rodrigues Pereira; Carlos Eduardo Negrão; de Nazaré Nunes Maria Janieire Alves

doi:10.1055/a-1518-7953

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2022; 43(02): 183-191
DOI: 10.1055/a-1518-7953

Clinical Sciences

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users

Francis Ribeiro de Souza

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Marcelo Rodrigues dos Santos

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Carlos Eduardo Rochitte

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Rafael Parenquine dos Santos

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Camila Paixão Jordão

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Ivanhoe Stuart Leite

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Guilherme Wesley Peixoto da Fonseca

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Rafael Almeida Fonseca

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Tiago Franco de Oliveira

²Departamento de Farmacociências da Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil

,

Maurício Yonamine

³Departamento de Análises Clínicas e Toxicológicas da Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, São Paulo, Brazil

,

Rosa Maria Rodrigues Pereira

⁴Laboratório de Metabolismo Ósseo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

,

Carlos Eduardo Negrão

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

⁵Escola de Educação Física e Esporte da Universidade de São Paulo, São Paulo, Brazil

,

de Nazaré Nunes Maria Janieire Alves

¹Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

› Author Affiliations

Abstract

Anabolic androgenic steroid (AAS) abuse leads to myocardial toxicity. Human studies are conflicting about the myocardial fibrosis in AAS users. We evaluated cardiac tissue characterization, left ventricle (LV) function, and cardiac structure by cardiovascular magnetic resonance (CMR). Twenty strength-trained AAS users (AASU) aged 29±5 yr, 20 strength-trained AAS nonusers (AASNU), and 7 sedentary controls (SC) were enrolled. Native T1 mapping, late-gadolinium enhancement (LGE), extracellular volume (ECV), and myocardial strain were evaluated. AASU showed lower Native T1 values than AASNU (888±162 vs. 1020±179 ms p=0.047). Focal myocardial fibrosis was found in 2 AASU. AASU showed lower LV radial strain (30±8 vs. 38±6%, p<0.01), LV circumferential strain (–17±3 vs. −20±2%, p<0.01), and LV global longitudinal strain (–17±3 vs. –20±3%, p<0.01) than AASNU by CMR. By echocardiography, AASU demonstrated lower 4-chamber longitudinal strain than AASNU (–15±g3 vs. –18±2%, p=0.03). ECV was similar among AASU, AASNU, and SC (28±10 vs. 28±7 vs. 30±7%, p=0.93). AASU had higher LV mass index than AASNU and SC (85±14 vs. 64±8 vs. 58±5 g/m², respectively, p<0.01). AAS abuse may be linked to decreased myocardial native T1 values, impaired myocardial contractility, and focal fibrosis. These alterations may be associated with maladaptive cardiac hypertrophy in young AAS users.

Key words

T1 mapping - cardiac contractility - anabolic androgenic steroids

Full Text

References

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Supplementary Material